HSA & FSA eligible

Prescription required. A licensed provider determines eligibility and treatment; kit contents may vary. Use only as directed and do not share medications. Amble does not provide medical care or dispense medications; care and prescriptions are provided by licensed providers and pharmacies. Compounded medications, if prescribed, are not FDA approved or reviewed for safety, effectiveness, or quality.

Radiation Emergency Kit

Oh Sh*t Kit

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$345

The Oh Sh*t Kit is built for one specific emergency: radiation exposure. If the unthinkable happens, whether from an accident, disaster, or other radiological event, having the right medications on hand can make a critical difference in the earliest hours. Because when radiation is involved panic is optional, but preparation isn’t.

  • Includes essential emergency preparedness medications for radiological exposure scenarios
  • Prescribed by a licensed medical provider
  • Preparedness-focused support when immediate access to care may be limited
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Important safety information

Important Safety Information

Refer to the following important safety details for information on intended use, potential side effects and risks, considerations for specific groups, and possible drug interactions linked to the prescription treatments mentioned.

Amble encourages users to promptly report any side effects or adverse reactions to a licensed healthcare provider and the pharmacy that dispensed the medication. To report suspected reactions, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.

For emergencies, call 911 or go to your nearest emergency department.

Advertisements by Amble

All advertisements from joinamble.com are paid for by Amble Health, Inc. and are intended to market Amble’s services. Some advertisements may feature paid actors or dramatizations. When real Amble customers or endorsements are included, this will be clearly disclosed. Individual results may vary, and specific outcomes are not guaranteed.

Amble’s Role

Amble connects users with licensed healthcare providers for evaluations regarding the suitability of the treatments advertised. It may also assist with prescription coordination through an external pharmacy network.

Amble acts as a managed services provider and does not offer medical advice, fill prescriptions, or function as a licensed healthcare facility or pharmacy. Instead, it provides technology and administrative support to enable medical consultations and prescription logistics. For further details, see Amble’s Terms of Service.

Promotional Offers on joinamble.com

Occasionally, joinamble.com may present promotional pricing or special introductory offers. These promotions are valid for 24 hours after they are removed from the website.

The claim “same price at every dose” is subject to the following:

• Pricing may change at any time due to supply or market conditions at the discretion of joinamble.com.

• Any “same price at every dose” promotion expires within 24 hours of any price updates.

• Introductory or promotional pricing, including “first month” offers, are not governed by the “same price per dose” policy and only apply to full-price products as listed on the website.

Prescriptions and Medications

Prescription drugs require evaluation and approval by a qualified healthcare provider, and issuance is solely at the provider’s discretion. Access to treatment plans and medications is not assured.

Prescriptions issued through Amble may be filled by licensed pharmacies within its affiliated network.

All prescription medications involve potential risks. Please review all associated safety details and consult your provider for personalized advice.

Compounded Drug Formulations

In certain situations, healthcare providers may prescribe compounded medications, which are custom-prepared by licensed compounding pharmacies based in the U.S. These medications are not FDA-approved for safety or effectiveness but may be used when alternatives are not available or appropriate.

Amble helps facilitate both FDA-approved and compounded medication fulfillment via its partner pharmacy network. These formulations are personalized to meet individual patient requirements and may differ from commercial products.

Trademark Notice

Mounjaro® and Zepbound® are registered trademarks owned by Eli Lilly and Company. Amble is not affiliated with or endorsed by the manufacturers of any brand-name medications. For further information, visit Eli Lilly’s official website.

Contact Information

For any questions about Amble’s services or advertising content, please reach out to: [email protected].

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Semaglutide

Important Safety Information Regarding Compounded Semaglutide Products

Please be aware that compounded drugs are not FDA-approved and do not undergo clinical studies to evaluate for safety and efficacy, similar to FDA-approved commercially available products. Compounded products may still be legally prescribed, and your healthcare provider may issue you a prescription for compounded semaglutide based on your medical consultation.

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of:

  • 30 kg/m2 or greater (obesity) or
  • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).

Speak with your healthcare provider to see if semaglutide may be right for you.

Semaglutide may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, semaglutide caused thyroid tumors, including thyroid cancer. It is not known if semaglutide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans.

Who should not use semaglutide:

  • Do not use semaglutide if you or any family member has ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use semaglutide if you have had a serious allergic reaction to semaglutide in the past.

Before starting semaglutide, tell your healthcare provider if you have any other medical conditions, including if you:

  • Have or have had problems with your pancreas or kidneys.
  • Have type 2 diabetes and a history of diabetic retinopathy.
  • Have or have had depression, suicidal thoughts, or mental health issues.
  • Are pregnant or plan to become pregnant. Semaglutide should not be used during pregnancy and there may be potential risks to an unborn baby from exposure to semaglutide during pregnancy. You should stop using semaglutide for at least 2 months before you plan to become pregnant.
  • Are breastfeeding or plan to breastfeed. It is not known if semaglutide passes into your breast milk.

Tell your healthcare provider about all the medicines you take. This includes prescription medications, over-the-counter medicines, vitamins, and herbal supplements. Semaglutide may affect the way some medicines work, and some medicines may affect the way semaglutide works.

Serious side effects can occur with semaglutide. You or a caregiver should carefully monitor for these side effects, especially in the beginning of treatment and with dosage changes. Semaglutide may cause serious side effects, including:

  • Thyroid C-Cell Tumors. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, semaglutide caused thyroid tumors, including thyroid cancer. It is not known if semaglutide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans.
  • Paralysis of the stomach (gastroparesis). The symptoms of gastroparesis may include feeling full shortly after starting a meal, feeling full long after eating a meal, nausea, and vomiting. Contact your healthcare provider if you experience any of these symptoms.
  • Inflammation of your pancreas (pancreatitis). Stop using semaglutide and contact your healthcare provider immediately if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting.
  • Gallbladder problems. Semaglutide may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Contact your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take semaglutide.
  • Kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration.
  • Serious allergic reactions. Stop using semaglutide and seek medical attention if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
  • Change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision with semaglutide.
  • Increased heart rate. Semaglutide may increase your heart rate while you are at rest. Talk to your healthcare provider if you feel your heart racing or pounding.
  • Depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Contact your healthcare provider immediately if you have any mental changes that are new, worse, or worry you.

The most common side effects of semaglutide may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, heartburn, and runny nose or sore throat.

If you are experiencing a medical emergency, call 911 or seek immediate medical attention.

You are encouraged to report negative side effects of prescription products:

Semaglutide administration. Semaglutide can be taken with or without food. The medication is self-administered as a subcutaneous injection in the stomach, thigh, or upper arm once a week on the same day every week. For detailed instructions on how to administer your dose, please speak with your healthcare provider. They will guide you on a treatment regimen and explain to self-administer the medication. You should not change your dosing regimen or stop taking semaglutide as prescribed without first discussing with your healthcare provider.

This information is not comprehensive. Please discuss with your healthcare provider any questions or concerns you have regarding semaglutide.

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Tirzepatide

Important Safety Information Regarding Compounded Tirzepatide Products

Please be aware that compounded drugs are not FDA-approved and do not undergo clinical studies to evaluate for safety and efficacy, similar to FDA-approved commercially available products. Compounded products may still be legally prescribed, and your healthcare provider may issue you a prescription for compounded tirzepatide based on your medical consultation.

Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of:

  • 30 kg/m2 or greater (obesity) or
  • 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnea or cardiovascular disease).

Speak with your healthcare provider to see if tirzepatide may be right for you.

Tirzepatide may cause serious side effects, including:

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, tirzepatide caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors. It is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans.

Who should not use tirzepatide:

  • Do not use tirzepatide if you or any family member has ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Do not use tirzepatide if you have had a serious allergic reaction to tirzepatide in the past.

Before starting tirzepatide, tell your healthcare provider if you have any other medical conditions, including if you:

  • Have or have had problems with your pancreas or kidneys.
  • Have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems with digesting food.
  • Have a history of diabetic retinopathy.
  • Have or have had depression, suicidal thoughts, or mental health issues.
  • Are pregnant or plan to become pregnant. Tirzepatide should not be used during pregnancy and there may be potential risks to an unborn baby from exposure to tirzepatide during pregnancy. You should discuss with your healthcare provider whether and how you should stop using tirzepatide before you plan to become pregnant.
  • Are breastfeeding or plan to breastfeed. It is not known if tirzepatide passes into your breast milk.

Tell your healthcare provider about all the medicines you take. This includes prescription medications, over-the-counter medicines, vitamins, and herbal supplements. Tirzepatide may affect the way some medicines work, and some medicines may affect the way tirzepatide works. If you are taking medicines to treat diabetes, including insulin or sulfonylureas, please let your healthcare provider know as tirzepatide could increase your risk of low blood sugar.

Serious side effects can occur with tirzepatide**. You or a caregiver should carefully monitor for these side effects, especially in the beginning of treatment and with dosage changes. Tirzepatide** may cause serious side effects, including:

  • Thyroid C-Cell Tumors. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, tirzepatide caused thyroid tumors, including thyroid cancer. It is not known if tirzepatide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans.
  • Paralysis of the stomach (gastroparesis). The symptoms of gastroparesis may include feeling full shortly after starting a meal, feeling full long after eating a meal, nausea, and vomiting. Contact your healthcare provider if you experience any of these symptoms. Tirzepatide has not been studied in patients with severe gastrointestinal disease, including severe gastroparesis, and is therefore not recommended in these patients.
  • Inflammation of your pancreas (pancreatitis). Stop using tirzepatide and contact your healthcare provider immediately if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting.
  • Gallbladder problems. Tirzepatide may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Contact your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools.
  • Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take tirzepatide.
  • Kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration.
  • Serious allergic reactions. Stop using tirzepatide and seek medical attention if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.
  • Change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision with tirzepatide.
  • Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use tirzepatide with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.
  • Depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Contact your healthcare provider immediately if you have any mental changes that are new, worse, or worry you.

The most common side effects of tirzepatide include: nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of tirzepatide. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

If you are experiencing a medical emergency, call 911 or seek immediate medical attention.

You are encouraged to report negative side effects of prescription products:

Tirzepatide administration. The medication is self-administered as a subcutaneous injection in the stomach, thigh, or upper arm once a week on the same day every week. For detailed instructions on how to administer your dose, please speak with your healthcare provider. They will guide you on a treatment regimen and explain to self-administer the medication. You should not change your dosing regimen or stop taking tirzepatide as prescribed without first discussing with your healthcare provider.

This information is not comprehensive. Please discuss with your healthcare provider any questions or concerns you have regarding tirzepatide.

HSA & FSA eligible
HSA & FSA eligible

Prescription required. A licensed provider determines eligibility and treatment; kit contents may vary. Use only as directed and do not share medications. Amble does not provide medical care or dispense medications; care and prescriptions are provided by licensed providers and pharmacies. Compounded medications, if prescribed, are not FDA approved or reviewed for safety, effectiveness, or quality.

How do I order?

Click Get Started to begin the process. Next you will answer some questions about your health history, medical allergies, and lifestyle via our online medical intake. A licensed medical provider will then review your information and determine if the Kit is right for you. If prescribed, your Kit is shipped directly to your door at no extra cost.

Can I order refills?

You can order an Amble Med Kit annually for each person in your household that meets our requirements. You can order an additional Med Kit to keep at a different location. This will allow you to order up to 4 full Med Kits per year, per person, providing they are kept at different locations. Important Note: We do not condone the stockpiling of medications. Medications purchased through Amble are for the sole purpose of having the appropriate emergency medications on hand when and where you need them, and only should be used in the event you cannot access medical help.

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Can I order multiple kits?

Yes. You are eligible to purchase an Amble Med Kit for additional locations. For those who have a legitimate reason to own an additional Med Kit, you can apply for approval during the standard checkout process.

Example of eligible situations:
• Store in your vehicle
• Second home address
• RV or Motorhome
• Cabin
• Boat or Houseboat
• Office/Work

Medication and packaging may vary based on your personalized treatment plan and prescription. Compounded products are not approved or evaluated for safety, efficacy, or quality by the FDA.

Whats included

Get started
Potassium Iodide
130 mg (generic iOSAT/ThyroSafe)
14 tablets
Prussian Blue
500 mg (Ferric Hexacyanoferrate; generic Radiogardase™)
6 capsules
Ondansetron ODT
4 mg (generic Zofran™)
6 tablets

How it works

Get Started
Step 1

Free assessment, 100% online

Answer some questions about your health history, lifestyle, and goals via our online medical intake.

Step 1
Take the assessment
Step 2

Prescription

A licensed medical provider will review your information and determine if the medication is right for you.

Step 2
Find out if I am eligible
Step 3

Free delivery

If prescribed, your medication is 
cold-shipped directly to your door at no extra cost.

Step 3
Get started

Radiation Emergency Kit benefits

Get started

Radiation Ready

Prepared for the moments that matter most.

Critical Early Support

Essential medications when timing is everything.

Peace of Mind

Know you're ready for the unexpected.

Provider Prescribed

Reviewed by a licensed medical provider and tailored to you.

Why Amble?

Doctor-trusted medication

Your healthcare should reflect your uniqueness. We design every plan with you in mind—your goals, your needs, your journey.

Licensed physicians

Get prescription medications tailored to your personal goals—so you always have what you need to feel your best.

On-going support

Access expert guidance, answers, and continuous care—100% online, whenever you need it.
Get started

Your questions, answered.

Who can order an Amble Med Kit?

This is an RX product. To ensure compliance, orders are limited to you or a dependent using your verified email. To order for others, please purchase a gift card or contact Customer Service.

How do I store my kit?

It is recommended to store medications in air-tight containers in a cool and dry environment. However, storage requirements can vary for different medications, so we recommend consulting with your healthcare professional regarding proper storage conditions.

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How long can the medications be stored?

Regulations require a pharmacist to place an expiration date of one year on most medications that they dispense. Remember to always store your medication in a cool dry place to maximize its viability.

Does Amble encourage stockpiling medications?

No, Amble does not encourage or condone the stockpiling of medications. Our emergency Med Kits are intended solely for limited and responsible preparedness in case of unexpected emergencies or disasters where access to medical care may be limited.

How often can I reorder my medications

You can order an Amble Med Kit annually for each person in your household that meets our requirements. You can order an additional Med Kit to keep at a different location. This will allow you to order up to 4 full Med Kits per year, per person, providing they are kept at different locations.

What if I have an allergy to a specific medication in the kit?

If you have a known allergy to medication, you can note that during the enrollment process. Based on the medical history and allergy information provided during the enrollment process, one or more medications may not be prescribed in your kit without substitution.

Can I share my kit with other family members?

Amble only offers individual kits that are prescribed to the individual who filled out the order form. The physicians prescribe based upon the answers to the questions on that form. If there is an allergy notated on the form, we need to account for that allergy and make sure that others are not using the medications that could potentially be harmful to them. These are emergency medications and should be treated the same way as any other prescription that is prescribed by a physician.

Can I order multiple kits?

Yes. You are eligible to purchase an Amble Med Kit for additional locations. For those who have a legitimate reason to own an additional Med Kit, you can apply for approval during the standard checkout process.

Example of eligible situations:
• Store in your vehicle
• Second home address
• RV or Motorhome
• Cabin
• Boat or Houseboat
• Office/Work

Can I order refills?

You can order an Amble Med Kit annually for each person in your household that meets our requirements. You can order an additional Med Kit to keep at a different location. This will allow you to order up to 4 full Med Kits per year, per person, providing they are kept at different locations. Important Note: We do not condone the stockpiling of medications. Medications purchased through Amble are for the sole purpose of having the appropriate emergency medications on hand when and where you need them, and only should be used in the event you cannot access medical help.

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Do I need insurance?

No, Amble does not require insurance. We provide transparent, all-inclusive pricing for your care. This includes comprehensive clinical support — ongoing provider oversight, direct access to your care team through secure messaging, and regular medication shipments. Our goal is to ensure you receive continuous medical guidance and support throughout your treatment.

Still have questions?

Oh sh*t, you’re prepared

Kits prescribed by a licensed medical provider.

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Medication Guide

General Disclaimer                                                 
These medications should always be used responsibly and after consultation with a qualified healthcare professional or primary care provider for diagnosis and treatment instructions before utilizing any medications in your kit. If you have any questions, Amble offers a team of licensed medical professionals to help.

Storage Information                                                                                    
Most solid oral drugs have a longer shelf life when stored at room temperature (68–77°F / 20–25°C) and shielded from UV radiation in airtight containers. The FDA's Shelf-Life Extension Program showed that many solid form medications stayed potent beyond their expiration date.

Medication Information

POTASSIUM IODIDE

(generic iOSAT/ThyroSafe)

Pharmacologic Category: Thyroid blocking agent; radiation medical countermeasure

FDA-Approved Uses:

  • Helps prevent radioactive iodine from getting into the thyroid gland during a nuclear radiation emergency
  • Use along with other emergency measures recommended by public officials

Common Off-Label Uses:Use is generally limited to public health, radiation emergency, or toxicologic guidance. Potassium iodide should not be used for routine "radiation protection" or for exposure to radioactive materials other than radioactive iodine.

Typical Adult Dosing:

Thyroid Block (After nuclear radiation emergency)1 pill by mouth 1 time per day, continue daily for 10–14 days or until directed by public health officials or risk of exposure has passed

Pregnancy: Pregnancy Risk Category D (see Appendix A). Potassium iodide is approved for use during a nuclear radiation emergency. Pregnant patients are at higher risk of developing thyroid dysfunction and thyroid cancer and should be prioritized for treatment.

Breastfeeding: Potassium iodide is present in breast milk. This medication is approved for use during a nuclear radiation emergency. Breastfeeding patients are at higher risk of developing thyroid dysfunction and thyroid cancer and should be prioritized for treatment.

Notes:

  • Potassium Iodide protects only the thyroid gland from radioactive iodine. It does not protect the rest of the body and does not protect against other radioactive materials.
  • Potassium Iodide is most effective when taken within 24 hours before or within 4 hours after radioactive iodine exposure.
  • Do not take Potassium Iodide unless instructed by public health officials or a medical provider.
  • Potassium Iodide does not reverse thyroid damage that has already occurred and may not provide complete thyroid protection.

Common Side Effects: Heart rate irregularity, numbness and tingling, confusion, fatigue, fever, numbness, acne vulgaris, rash, hives, goiter, diarrhea, gingival pain, metallic taste, nausea, stomach pain, toothache, vomiting, joint pain, weakness, shortness of breath, and wheezing.

Contraindications: Allergy or hypersensitivity to iodide or iodine. History of dermatitis herpetiformis, certain types of vasculitis, or nodular thyroid condition with heart disease.

Caution: Caution in people with known thyroid disease. Chronic use can lead to hypothyroidism. Caution and speak with a medical provider if you take potassium sparing diuretics (like spironolactone or eplerenone).

PRUSSIAN BLUE

(Ferric Hexacyanoferrate; generic Radiogardase™)

Pharmacologic Category: Antidote, decorporation agent

FDA-Approved Uses:

  • Treatment of patients with known or suspected internal contamination with radioactive cesium
  • Treatment of patients with known or suspected internal contamination with radioactive thallium
  • Treatment of patients with known or suspected internal contamination with non-radioactive thallium

Common Off-Label Uses:Use is generally limited to radiological or toxicologic exposure management under medical, toxicology, or public health direction. Prussian Blue is not effective for all radioactive materials and should only be used when clinically indicated.

Typical Adult Dosing:

Internal contamination with radioactive cesium and/or radioactive or non-radioactive thalliumTake Prussian Blue 3 grams by mouth THREE TIMES A DAY

Treatment duration is individualized based on contamination levels, symptoms, elimination monitoring, and medical/public health guidance.

Pregnancy: No adequate and well-controlled studies in pregnant women. Use during pregnancy may be considered when the potential benefit of reducing internal contamination outweighs potential risk. Consult with a medical provider, toxicologist, or public health authority.

Breastfeeding: Prussian Blue is not expected to be absorbed from the gastrointestinal tract, so excretion into breastmilk is unlikely. However, cesium and thallium can pass from mother to infant through breastmilk. Women internally contaminated with cesium or thallium should not breastfeed unless directed by a medical provider or public health authority.

Notes: Prussian Blue works by binding cesium and thallium in the gastrointestinal tract, helping increase elimination through bowel movements. It does not treat contamination with all radioactive materials and does not reverse radiation injury that has already occurred. It should be started as soon as possible after internal contamination with cesium or thallium is suspected, under appropriate medical/public health direction.

Common Side Effects: Constipation, upset stomach, abdominal discomfort, nausea, vomiting, diarrhea, blue discoloration of stool.

Contraindications: DO NOT TAKE if known allergy or hypersensitivity to Prussian Blue, ferric hexacyanoferrate, or any component of the formulation.

Caution: Use only under medical, toxicology, or public health guidance for known or suspected cesium or thallium contamination. Prussian Blue may bind some orally administered medications or nutrients and may reduce their absorption. Constipation may reduce effectiveness by slowing elimination and should be managed under medical direction. Medical monitoring may include contamination measurements, symptom assessment, electrolytes, and stool output depending on exposure type and severity.

ONDANSETRON 4 mg

(generic Zofran™)

Pharmacologic Category: Antiemetic; Selective 5-HT₃ Receptor Antagonist

FDA-Approved Uses:

  • Cancer chemotherapy-induced nausea and/or vomiting
  • Postoperative nausea and/or vomiting
  • Radiotherapy-associated nausea and/or vomiting

Common Off-Label Uses:

  • Nausea and/or vomiting, acute, severe
  • Pregnancy-associated nausea and/or vomiting
  • Vertigo-associated nausea and/or vomiting

Typical Adult Dosing:

Nausea and/or vomiting, acute, severeTake Ondansetron 4 mg (1 tablet) by mouth EVERY 4 to 8 HOURS, as needed for nausea or vomiting****Do not exceed 16 mg (4 tablets) in a 24-hour period

Pregnancy: Pregnancy Risk Category B (see Appendix A). Consult with a medical provider.

Breastfeeding: Presence in human breast milk is unknown. Potential harm to breastfeeding infants is unknown. Consult with a medical provider.

Notes: Ondansetron may be taken with food or on an empty stomach. Take with a full glass of water.

Common Side Effects: Headache, constipation, diarrhea, dizziness, drowsiness, fatigue, and malaise.

Contraindications: DO NOT TAKE if known allergy or hypersensitivity to Ondansetron (Zofran™), or any other component of the formulation; DO NOT TAKE with apomorphine.

Caution: Significant drug interactions exist and may require dose/frequency adjustment or avoidance. Additional considerations in persons taking other serotonergic agents (e.g. SSRIs, SNRIs, MAOIs) or with a history of Serotonin syndrome. May cause dizziness/drowsiness, advise caution while driving.

Please review the full package insert and consult with a medical provider for additional information.

Appendix A: Pregnancy, Lactation, and Reproductive Potential Labeling

Purpose of This Appendix

This appendix summarizes how pregnancy, breastfeeding, and reproductive potential information should be interpreted in medication education materials. This appendix is based on the FDA Pregnancy and Lactation Labeling Rule (PLLR) framework for prescription drug labeling.

The FDA no longer uses the pregnancy letter categories A, B, C, D, and X in current prescription drug labeling. These categories were removed because they were considered confusing and overly simplistic and did not adequately communicate medication risk during pregnancy, lactation, or reproductive decision-making.

Current FDA labeling uses narrative risk information to help healthcare providers assess benefit and risk and counsel pregnant patients, breastfeeding patients, and patients of reproductive potential.

8.1 Pregnancy

Under current FDA labeling, the Pregnancy subsection may include the following elements when applicable:

Pregnancy Exposure RegistryIf a pregnancy exposure registry exists for a medication, labeling may include information about the registry and how pregnant patients may enroll or obtain additional information.

Risk SummaryThe pregnancy risk summary provides a concise summary of what is known about medication use during pregnancy. It may include available human data, animal data, and pharmacologic information when relevant.

The risk summary may address whether available data identify a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

Clinical ConsiderationsThis section may include clinically relevant information such as:

  • Disease-associated maternal and/or embryo/fetal risk
  • Dose adjustments during pregnancy and postpartum period
  • Maternal adverse reactions
  • Fetal/neonatal adverse reactions
  • Labor or delivery considerations when applicable

DataThis section may summarize the human and/or animal data supporting the risk summary.

8.2 Lactation

Under current FDA labeling, the Lactation subsection may include the following elements when applicable:

Risk SummaryThe lactation risk summary may describe:

  • Whether the medication is present in human milk
  • Whether the medication affects the breastfed child
  • Whether the medication affects milk production
  • Relevant human or animal lactation data, if available

When human lactation data are available, FDA labeling gives priority to human data over animal data. If breastfeeding is contraindicated, that information should be stated first in the risk summary.

Clinical ConsiderationsThis section may include recommendations for minimizing exposure, monitoring the breastfed child, or managing potential adverse reactions when applicable.

DataThis section may summarize available human or animal lactation data, including measured drug levels in milk or infant exposure estimates when available.

8.3 Females and Males of Reproductive Potential

Under current FDA labeling, this subsection may include information about:

  • Pregnancy testing
  • Contraception
  • Infertility

This section is included when a medication may affect pregnancy status, fertility, embryo-fetal development, or reproductive decision-making.

Legacy Pregnancy Letter Categories

The FDA has removed the pregnancy letter categories A, B, C, D, and X from prescription drug labeling. These categories may still appear in older reference materials, older product labels, or legacy clinical documents, but they are not the current FDA labeling standard.

When a legacy category appears in this medication guide, it should be interpreted only as historical labeling language. Current prescribing information should be reviewed for the most up-to-date pregnancy risk summary.

Legacy Category AAdequate and well-controlled studies in pregnant women failed to demonstrate a risk to the fetus in the first trimester, and there is no evidence of risk in later trimesters.

Legacy Category BAnimal reproduction studies failed to demonstrate fetal risk, but there are no adequate and well-controlled studies in pregnant women.orAnimal studies showed an adverse effect, but adequate and well-controlled studies in pregnant women failed to demonstrate fetal risk.

Legacy Category CAnimal reproduction studies showed an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans.orNo animal reproduction studies and no adequate and well-controlled studies in humans are available.

Potential benefits may warrant use in pregnant women despite potential risks.

Legacy Category DThere is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans.

Potential benefits may warrant use in pregnant women despite potential risks.

Legacy Category XStudies in animals or humans demonstrated fetal abnormalities.orThere is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans.

The risks involved in use during pregnancy clearly outweigh potential benefits.

Standard Pregnancy Language for Medication Sheets

Use one of the following FDA-aligned language structures when drafting medication sheets:

When current labeling provides a clear pregnancy risk statementPregnancy: Current labeling states [insert label-based risk summary]. Consult with a medical provider before use during pregnancy.

When human pregnancy data are limitedPregnancy: Available human data are limited and are not sufficient to establish a drug-associated risk. Use during pregnancy only if the potential benefit justifies the potential risk. Consult with a medical provider.

When medication should be avoided at a specific pregnancy stagePregnancy: Avoid use during [insert trimester/week range] unless specifically advised by a medical provider due to [insert label-supported risk]. Consult with a medical provider.

When medication is contraindicated in pregnancyPregnancy: Use is contraindicated during pregnancy. Do not use if pregnant or planning to become pregnant unless labeling or a medical provider specifically indicates otherwise.

Standard Breastfeeding Language for Medication Sheets

Use one of the following FDA-aligned language structures when drafting medication sheets:

When medication presence in human milk is unknownBreastfeeding: It is not known whether this medication is present in human milk, whether it affects the breastfed infant, or whether it affects milk production. Consult with a medical provider before use while breastfeeding.

When medication is present in human milkBreastfeeding: This medication is present in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for treatment and any potential adverse effects on the breastfed child. Consult with a medical provider.

When medication is expected to produce low infant exposureBreastfeeding: Available data suggest infant exposure through breastmilk is expected to be low. Consult with a medical provider before use while breastfeeding, especially when nursing a newborn or preterm infant.

When breastfeeding is not recommendedBreastfeeding: Breastfeeding is not recommended during treatment with this medication and for [insert duration, if specified in labeling] after the last dose. Consult with a medical provider for individualized guidance.

When breastfeeding is contraindicatedBreastfeeding: Use is contraindicated during breastfeeding. Do not breastfeed during treatment unless current prescribing information or a medical provider specifically indicates otherwise.

Standard Disclaimer

This appendix is for medication education and labeling consistency only. It does not provide medical advice, diagnose any condition, recommend treatment, or replace the full prescribing information, product label, FDA-approved labeling, or guidance from a licensed medical provider. Current prescribing information should be reviewed because pregnancy, lactation, and reproductive-risk information may change as new data become available.

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